BIBLIOGRAPHY   Donald L. MacKeen, Ph.D. Partial Listing of publications and Patents 1. Gabay S. Valcourt A and MacKeen DL, "Preparation of a highly purified monoamine oxidase (MAO)" Fed. Proc. 25(2): 319 (1966) 2. Fine S Feigen L. MacKeen DL and Klein E, "Hazards and protective devices associated with 10.6u radiation." Proc. Ann. Conf. Engineer._ Med. Biol. 9:52 (1967) 3. Fine S. Edlow J MacKeen DL, Feigen L Ostrea E and Klein E "Focal hepatic injury and repair produced by laser radiation" Am. J. Pathol. 52(l): 155-176 (1968) 4. MacKeen DL, Fine S and Klein E,, "Toxic and explosive hazards associated with lasers". Laser Focus, Oct. 1968, pp 44-49 5. Feigen L, MacKeen DL and Fine S,, "A method for detecting and measuring frequency of surface vibrations using a helium-neon laser" Rev. Sci. Instrum. 40:381 (1971) 6. MacKeen DL, Fine S. Feigen L and Fine BS,, "Anterior chamber measurements on carbon dioxide laser corneal irradiation" Invest. Ophthalmol. 9(5): 366-371 (1970) 7. Fine S, MacKeen DL, Berkow JW and Fine BS, "Preliminary report of biologic testing of laser protective materials", Am J Ophthalmol, 71(4): 828-834 (1971) 8. MacKeen DL, Fine S, Aaron A and Fine BS, "Cataract production in rabbits with an ultraviolet laser." Laser Focus April. 1971 p 27 9. MacKeen DL and Fine S. "Effects of suprathreshold carbon dioxide laser irradiation of the weanling rabbit eye on lenticular concentrations of ascorbic acid and reduced glutathione. Fed. Proc. 32(3): 348 (1973) 10. MacKeen DL, Szabo G and Fine S "The effects of UV laser radiation at 325 nm on the skin" Yale J. Med 1973 11. Szabo GT, MacKeen DL and Fine S, "The ultrastructural effects of ultraviolet laser radiation on skin" Ann Italiani Dermatol. Clin Sperimen. 28(2): 1974 12. MacKeen DL, Fine S and Fine BS, "Production of cataracts in rabbits with the UV laser " Ophthalmic Res. 5: 3176 (1973) 13) MacKeen DL and Fine BS, "Repair of epithelial abrasions in rabbit and rhesus monkey" Invest. Ophthal , Suppl April 1975 p 40 13. Green K and MacKeen DL 'Chloramphenicol retention on and penetration into the eye", Invest ophthalmol 15: 220-222 (1976) 14. MacKeen DL and Labaw, B," A method of fitting soft hydrophilic contact lenses to rabbits for long term experiments" Int Contact Lens Clinic July/August :65(1978) 15. MacKeen DL and Green, K "Chlorhexidine kinetics of hydrophilic contact lenses" J Pharm Pharmacol 30:714(1978) [Listed as suggested method in FDA Guidelines for contact lens testing from 1980 to 1995] 16. MacKeen DL and Green, K "Chlorhexidine kinetics of hard contact lenses" J Pharm Pharmacol 31: 7814(1979) 17. MacKeen DL, "on an in vitro method of simulating drug release from viscous eye drops" Pharm Pharmacol 31:872 (1979) 18. MacKeen, DL Translator of 'Kontaktlinsen' by Drs. HW Roth and M Roth-Wittig, published by Harper and Rowe, 1980 19. MacKeen DL,, "Aqueous formulations and Ointments in Ocular Pharmacology of the Anterior Segment , Ed.F Holly International Ophthalmology Clinic 3. 1980 Boston Little Brown, publishers 20. Lee WR, Murray SR, Williamson J and MacKeen DL "Human conjunctival mucinst a quantitative study of normal and diseased (KCS) tissue" A. v. Graefe's Archiv f. Ophthalmol. 215:209-221 (1981) 21. MacKeen DL, Kopp SJ, Greiner JV and Glonek T, "Effects of verapamil on metabolism of the crystalline lens: a phorphorus-31 nuclear magnetic resonance spectroscopic study' Invest Ophthalmol Suppl. 25(3): 104 (1984) 22. Roth HW and MacKeen DL "AIDS: Ein Risiko fuer Kontaktlinsenanpasser und Patient" Der Augenspiegel 31(12): 4-8 1985. 23. MacKeen DL, "Testing the Tears" Contact Lens Spectrum Feb 1986, pp 37-38 24. MacKeen DL, "Measuring Tear Qualities", Contact Lens Forum July 1986, pp 48-50 25. MacKeen DL, "Contact Lens Solutions: The Pharmacist's Role". Amer.Pharm. 26 (10): 27(1986) 26. MacKeen DL and Fine SF,, "Scattering of Near UV Radiation within Gel Contact Lens material", Invest Ophthalmol Suppl 28(3):164(1987) 27. Roth HW and MacKeen DL, "Experience with silicone punctum plugs in dry eye patients" Dakryology Meeting Budapest June 21, 1987 28. MacKeen, DL,"Schaeden beim Tragen von v.T. Linsen in den USA" Z. prakt. Augenheilkd 9:92-94 (1988) 29. MacKeen, DL and Roth HWI "Kontaktlinsen und AIDS', Z. prakt.. Augenheilkd. 9: 102-104 (1988) 30. Bush,JF, Huff,LW and MacKeen, DL."Laser-assisted contact angle measurements." Am. J. Optom. Phys. Optics 65: 722-728 (1988) 31. MacKeen, DL.Cavanagh HD, Homano, H and Hideji IF, "Overnight Swelling and Deswelling of Rabbit Corneas in Response to RGP and Soft Contact Lens Wear". Invest Ophthalmol Suppl 30(3):480(1989) 32. Cavanagh HD, Ichikawa H MacKeen DL Kazai A and Jester JV," Corneal Swelling Responses Differ with Extended Wear in Naive and Adapted Subjects with High Dk RGP Contact Lenses" Invest Ophthalmol Suppl 30(3):481(1989) 33. Ichikawa, H Kozai.A MacKeen DL and Cavanagh HD, "Corneal Swelling Responses with Extended Wear in Naive and Adapted Subjects with Menicon RGP Contact Lenses" CIAO J 15(3):192-195 (1989) 34. Roth HW and DL MacKeen "Erste Erfahrungen mit dem Disposable-Lens System" Der Augenspiegel 35, 2:5-7 (1989) 35. Ichijima I, MacKeen DL, Hamano H, Jester J and Cavanagh HD, "Swelling and deswelling of rabbit corneas in response to rigid gas permeable, hydrogel and elastomer contact lens wear." CLAO Journal 15(4):290-297 (1989) 36. MacKeen, DL and Roth HW "Successful maintenance of dry eye contact lens wearers with the punctum flow controller", Proceeedings of the VIIth International Contact Lens Symposium, Singapore, March 1990 37. Roth HW and MacKeen DL, "Therapeutic uses of disposable contact lenses", Proceeedings of the VIIth International Contact Lens Symposium Singapore, March 1990 38. Cavanagh HD, Hamano H, MacKeen DL and Lemp MA,, "Tear lactate dehydrogenase levels: a new method to assess effects of contact lens wear in a rabbit model and man, Invest Ophthalmol.31(4): 406 (1990) 39. MacKeen DL, Cavanagh HD, Ohashi J,, and Lemp MA. "Clinical results of extended war with a new high Dk rigid gas permeable contact lens in humans' Invest Ophthalmol.31(4): 407 (1990) 40. MacKeen, DL and Mircheff, A, 'Air pollution and the dry eye" presented at Second Meeting of the International Dakryology Society, Amsterdam, 25 July 1990 41. MacKeen DL and Roth HW, A method and apparatus for modulating the flow of lacrimal fluid through a punctum and associated canaliculus U.S. Patent 4,915,684, April 10, 1990 42. Kreiner C, Fink R, MacKeen, DL" New methods in the detection of silicone oil impurities" Silicone in Medical Decices, Conference Feb 1-2, 1991 Baltimore, USDPH p.319 43. Green, K, MacKeen, DL, Slagle T and Cheeks T,, " Tear Potassium contributes to maintenance of corneal thickness" Ophthalmic Research 24: 99-102 1991 44. MacKeen, DL. Fachdev,M. Ballou, V and Cavanagh, HD, "Results of a prospective multicenter clinical trial to assess the safety and efficacy of Menicon SFP rigid lenses for extended wear in human subjects" CLAO J 18 (3): 183-186 (1992) 45. MacKeen, DL US Patent 5,290,572 Ophthalmic composition for treating dry eye (1994) Assigned to DEO Corporation 46. Roth, HW and MacKeen DL , Micropachometric differentiation of dry eye syndromes in Lacrimal Gland and Dry Eye Syndromes pp505-512 Plenum Press, NY 1994 47. MacKeen, DL US Patent 5,366,739 Method of ophthalmic drug delivery (1994) Assigned to DEO Corporation 48. MacKeen DL Roth HW " Revolutionary method of ocular drug delivery IOVS 36(4): S166 (1995) 49. MacKeen, DL and Roth, HW, A preliminary report on a new method for the treatment of dry eye, Practical Optometry 6(3): 131-134 (1995) 50. MacKeen DL Roth HW and MacKeen PD, Supracutaneous treatment of dry eye patients with calcium carbonate, in Lacrimal gland , tear film and dry eye syndromes 2 Sullivan Ed. Plenum Press NY 1998 51. MacKeen DL Roth HW and MacKeen PD, Supracutaneous treatment of dry eye patients with calcium carbonate, in Lacrimal gland , tear film and dry eye syndromes 2 Sullivan Ed. Plenum Press NY 1998 52. MacKeen, PD, Roth HW and MacKeen, DL Treatment of dry eyed contact lens wearers with DEO, IOVS 37(3):S72, 1996 53. MacKeen DL Roth HW and Doane MA Ocular drug delivery by the LLD (lower lid delivery)Method IOVS 37(3):S77 1996 54. MacKeen DL Kontaktlinsen Hygiene bei disposable Systemen" Der Augenspiegel 42(9):17 (1996) 55. MacKeen, DL US Patent 5,595,764 Ophthalmic Composition for treating dry eye (1997) Assigned to DEO Corporation 56. MacKeen, DL, Roth,HW and MacKeen PD, Supracutaneous drug delivery to the eye" Presented at the 2nd International Symposium on Experimental and Clinical Ocular Pharmacology and Pharmaceutics, Munich, Germany, Sept 12, 1997 57. MacKeen, DL, Doane, MA and Roth HW," Fluorescent history of supracutaneous drug delivery to the pre-ocular tear film" IOVS 38(4)"S151 (1997) 58. MacKeen DL "Methods of Ophthalmic Drug Delivery" assigned to DEO Corporation, Australian Patent No. 986932, Sept 4, 1997 59. MacKeen, DL, Roth, HW, Doane MA and MacKeen, AAF, "Investigations of a new Ophthalmic drug delivery" Eye World, 3(4):64-66 April 1998 60. Isreb, MA, Greiner, JV, Korb, DR,Glonek T, Reddy,CC, Lee, EK, Kushak SL, Hearn D, and MacKeen DL," Human, rat and rabbit tear film lipid layer and interference pattern observations' IOVS 39(4): S532 (1998) 61. MacKeen DL Roth HW and MacKeen PD, Supracutaneous treatment of dry eye patients with calcium carbonate, in Lacrimal gland , tear film and dry eye syndromes 2 Sullivan Ed. Plenum Press NY 1998 62. MacKeen, D,L. Composition for Treating Dry Eye" assigned to DEO Corporation U.S. Patent 5,830,508 63. MacKeen, DL, "Composition for the treatment of dry eye syndrome" European Pat. 630 254 Jan 27,1999 Assigned to DEO Corporation 64. MacKeen, DL, "Method of Ophthalmic Drug Delivery", Canadian Patent 2,129,635. May 27,1999 assigned to DEO Corporation 65. MacKeen, D.L. "Metodo para aplicar farmaco oftalmico" Mexican patent No. 9307760 Issued September 3, 1999 to DEO Coproration 66. MacKeen, DL, "Zusammensetzungen zur Behandlung des trockenen Auges" German patent No. 693-23303 T2 to DEO Corporation 67. MacKeen, DL & Roth H-W "Simple Method Of Detecting The Anti-Inflammatory Action Of Topical Dry Eye Treatments", Presented at Third International Dry Eye Symposium< Maui Hawaii, Nov 2000. Scheduled for publication in Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3, Plenum Press 68. MacKeen DL "Potential New Treatments For Dry Eye" Part I Contact Lens Spectrum 16(2): 21-26 Feb (2001) [First of a 3 part series] 69. MacKeen DL "Potential New Treatments For Dry Eye" Part II Contact Lens Spectrum 16(3): 22-30 Mar (2001) 70. MacKeen DL "Potential New Treatments For Dry Eye" Part III Contact Lens Spectrum 16(4): 40-43 Apr (2001) 71. MacKeen, D.L. Composition for treating dry eye US Pat. 6,254,893 B1 July 3, 2001 72. MacKeen, DL and Roth HW "A simple method of detecting the anti-inflammatory actions of topical dry eye treatments" in Lacrimal Gland, Tear Film, amd Dry Eye Syndromes 3 p1227-1232, Ed., D Sullivan et al., Kluver Academic Press/Plenum Publishers, 2002 73. MacKeen,DL, Doane, M. 'Video history of supracutaneous movement from the lid skin into the preocular tears" TFOS Meeting Puerto Rico,2004, Abstract in The Ocular Surface, Vol.3 (1) Jan 2005 p. S32